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Calcium obeys the principles of input output balance (as do all the other substance we have discussed), but its regulation is fundamentally different from other substances we have considered because its balance is regulated predominantly by the gastrointestinal (GI) tract, although the kidneys play an important role In addition, like potassium, plasma calcium is strongly buffered by the large amounts of calcium in bone that is readily exchangeable with ECF calcium There are 2 time scales of calcium balance to consider: rapid transfer of calcium between the ECF and other tissues of the body and the slow rate of calcium ingestion into and excretion from the body Calcium in the ECF represents only a tiny fraction of total-body calcium, but its level is crucial for the function of cells in the body Thus, it is essential to maintain the concentration of free calcium in our ECF within a narrow range Too low a concentration leads to the life-threatening condition of low-calcium tetany (discussed later) Moment-to-moment regulation of extracellular calcium is achieved by shifting calcium in and out of bone Bone stores of calcium serve as an enormous buffer system capable of keeping plasma calcium nearly constant In essence, balance for calcium in the ECF is balance to and from bone, not the outside world Besides the rapid exchange of calcium into or out of bone, there is also a long-term regulation of total calcium in bone that is important for bone growth during childhood and bone integrity in adult life Here, the kidneys play an important but indirect role because they excrete calcium in the urine and are involved in forming the active form of vitamin D The dominant regulation of total-body calcium balance is less focused on output and more focused on input from the GI tract Interestingly, and in contrast to most substances considered thus far, absorption of dietary calcium is only partial In fact, most calcium that we eat simply passes through the GI tract to the feces Calcium is both reabsorbed and secreted in the gut The secretory rate is more or less constant, but the fraction absorbed is regulated to produce anywhere from small to moderate net absorption Some net absorption is essential for the longterm maintenance of adequate bone calcium Lack of calcium during childhood growth leads to a weak bone condition called rickets, and loss of calcium in an adult leads to osteomalacia or osteoporosis1 Normal levels of plasma calcium are about 10 mg/dL (25 mmol/L or 5 mEq/L) This calcium exists in 3 general forms First, almost half is in the free ionized (Ca 2+) form This is the only form that is biologically active in target organs Second, about 15% is complexed to anions with relatively low molecular weights, such as citrate and phosphate Third, the remaining 40% is reversibly bound to plasma proteins.

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Scripts running in the Windows Script Host are an essential part of Windows network administration As you know and begin to realize, scripting in Windows is a world of its own The scripting language has evolved to the point where a script is a sophisticated program that can be run in either graphic (intended for users) or character mode (administrative scripts) Running a script in either mode is controlled by the command you use to activate it: wscript scriptname cscript scriptname where wscript runs it in graphical mode and cscript runs it in character mode With the coming of script viruses such as ILOVEYOUvbs, you should make sure the scripts you run are secure The best way to do so is to sign your scripts with a digital certificate First you ll need to obtain the certificate This can be done from a third-party certificate authority, or it can be done by yourself if you decide to use your own certificate server (a server function available in Windows Server 2003) Use Procedure DC-11 to do so

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If you deploy the solution now, connect the Web Parts using the custom connection interface, enter a URL to a feed, and click the Submit button, you ll see that the consumer Web Part updates without refreshing the whole page. This simple change to the Web Parts and the connection interface is a small but efficient way to make the user interface of connected Web Parts and SharePoint faster.

Filter Web Parts are provider Web Parts used to filter the information in other Web Parts. For instance, a filter Web Part might define a date range that s used by another Web Part to filter its contents. SharePoint Server Enterprise is delivered with a set of filter Web Parts that you can use with your consumer Web Parts. Or you might create custom filter Web Parts to add new filtering functionality to your SharePoint installation. If you re working with SharePoint Foundation or SharePoint Server, you have no filter Web Parts at all by default, and you might find it worth your time to add your own.

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1 Rickets, osteomalacia, and osteoporosis are characterized by low calcium content in bone Rickets and osteomalacia are commonly associated with a low supply of calcium, typically because of low vitamin D Osteoporosis seems to represent improper regulation, so that the ongoing bone-forming and bonedissolving processes are dominated by bone dissolution

SCRIPT CENTER Signing a script with a certificate is a programmatic activity Sample signature addition and management scripts are available at the Microsoft TechNet Script Center at http:// wwwmicrosoftcom/ technet/treeview/defaultasp url=/ technet/scriptcenter/monitor/defaultasp frame=true

14.4.1 Default filter Web Parts A filter Web Part is a special kind of provider. Its sole purpose is to serve as a filter for another Web Part. Only the Server version of SharePoint 2010 contains filter Web Parts out of the box. Most of them are quite easy to implement on your own, if you need them in SharePoint Foundation. Table 14.2 shows the filter Web Parts in SharePoint Server.

Table 14.2 Out-of-the-box filter Web Parts in SharePoint Server Enterprise 2010 Description Filters a Web Part using values from the Business Data Connectivity service

You can also encode scripts to protect them You can find the Microsoft Script Encoder at http://msdnmicrosoftcom/ scripting/vbscript/download/x86/sce10enexe

regulation of CalCium and phosphate balanCe / 187

Name Business Data Connectivity Filter Choice Filter Current User Filter Date Filter Filter Actions Page Field Filter PerformancePoint Filter Query String Filter SharePoint List Filter SQL Server Analysis Server Filter Text Filter

SECURITY SCAN Every script you create and sign should be fully documented This documentation should include all pertinent information on the script and should be reviewed and kept up-to-date on a weekly basis

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