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The adaptive value of the first 3 effects should be obvious: They all result in a higher extracellular calcium concentration and thus compensate for the lower calcium concentration that originally stimulated PTH secretion Regarding the fourth effect, when PTH acts on bone, both calcium and phosphate are released into the blood Similarly, the active form of vitamin D enhances the intestinal absorption of both calcium and phosphate, so that the processes that are restoring calcium to its normal level are simultaneously tending to raise the plasma phosphate above normal But this is an unwanted action because an increase in dissolved phosphate causes a decrease in dissolved calcium Under the influence of PTH plasma phosphate does not actually increase, because of PTH s inhibition of tubular phosphate reabsorption Indeed, this effect is so potent that plasma phosphate may actually decrease when PTH levels are elevated The simultaneous presence of high levels of both calcium and phosphate can create pathologies in a number of tissues, including the heart and blood vessels, because this increases the formation of insoluble calcium phosphate complexes8 All of the above describes the effects of a rise in PTH induced by a fall in plasma calcium An increase in extracellular calcium concentration reduces PTH secretion, thereby producing increased urinary and fecal calcium loss and net movement of calcium from the ECF into bone PTH has other functions in the body, but the 4 effects discussed previously constitute the major mechanisms by which it integrates various organs and tissues in the regulation of extracellular calcium concentration The actions of PTH on bone are dependent on the pattern of its plasma concentration over time It can either promote resorption of hydroxyapatite (its usual action) or promote deposition Primary hyperparathyroidism, resulting from a primary defect in the parathyroid glands (eg, a hormone-secreting tumor), generates a continuous excess hormone level and causes enhanced bone resorption This leads to bone thinning and the formation of completely calcium-free areas or cysts In this condition, plasma calcium often increases and plasma phosphate decreases; the latter is caused by increased urinary phosphate excretion The increased plasma calcium modulates the activity of various body tissues A seeming paradox is that urinary calcium excretion is increased despite the fact that tubular calcium reabsorption is enhanced by PTH The reason is that the elevated plasma calcium concentration induced by the effects of PTH on bone (and via vitamin D on the load of calcium entering the body from the GI tract) causes the filtered load of calcium to increase even more than the reabsorptive rate Because the filtered load is so great, there is also an increased amount not reabsorbed (ie, excreted) This result nicely illustrates the necessity of taking both filtration and.

Knowing how and when to catch exceptions is important. Always check your parameters for null before using them. Eventually exceptions will get thrown and just catching

By default, terminal servers issue licenses to any computer 5 that requests one You must enable the License Server Security Group GPO setting (Computer Configuration | 5 Administrative Templates | Windows Components | Terminal Services | Licensing) to restrict TS sessions to authorized groups of computers or users only Use Procedure 5 DC-16 to do so, and make sure this policy is applied to all TS servers

an exception and ignoring it won t make it easier to troubleshoot the application. That will only leave you and your users unaware of any problems. Not all exceptions should be caught only catch exceptions that can be handled. Exceptions that can t be handled should instead fall through to SharePoint, which will eventually log the exception. There s a distinction between system exceptions and business logic errors. For instance, an Access Denied exception shouldn t always be handled; it can fall through to SharePoint, unless it s important for business logic to handle that exception. This isn t specific to SharePoint; it s good practice in all .NET development. In SharePoint with Web Parts it s important to do this correctly. A page in SharePoint can contain several Web Parts, and one single failing Web Part can make the whole page useless. One common method is to use a generic try-catch block that will catch any exception just to avoid displaying error messages to the users. Although using a trycatch block could keep the solution from displaying unwanted errors or sensitive information, this method of catching all exceptions makes users unaware of what went wrong and they ll have problems resolving or reporting the error. Being unaware of what failed in business-critical applications can be fatal. Consider an application making a financial transfer that fails and the user doesn t notice what made it fail:

8 The chemistry of the Ca phosphates is highly complex because Ca and phosphate can combine in different stochiometric ratios, and the tendency of any of these to precipitate depends on the concentrations not only of Ca and phosphate but also of other substances as well

void button_Click(object sender, EventArgs e) { try { float amount = float.Parse(textBox.Text); TransferMoney(amount); } catch (Exception) { label.Text = "Transfer failed"; return; } label.Text = "Succeeded"; }

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This snippet is a response to a button click; it takes the value of a text box and parses it into a float value before it uses a method to transfer the amount of money. The generic catch statement will catch all kinds of exceptions and inform the user that the transfer failed but not why. Even worse would be just catching the exception and not doing anything. In this simple example, users won t know whether they entered an invalid value or the money transfer failed. A better approach is in this case to catch only exceptions of the type FormatException. All other exceptions will be let through to the SharePoint exception handling.

regulation of CalCium and phosphate balanCe / 197

void button_Click2(object sender, EventArgs e) { try { float amount = float.Parse(textBox.Text); TransferMoney(amount); } catch (FormatException) { label.Text = "Invalid amount format"; return;

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} label.Text = "Succeeded"; }